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Accuracy
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gSynth Platform
3-fold increase in accuracy
Camena Bioscience’s technology is aimed at enabling synthetic biologists. Our site in Cambridge developed the gSynthTM technology, capable of producing a wide range of synthetic genes including complex sequences.
Over 300 bp gSynthTM produces DNA to 90% accuracy, whereas existing phosphoramidite DNA synthesis technology is just ~30% accurate.
Length
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Scale
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Sustainability
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A new era of DNA synthesis: next-level innovation
The ability to read, write, and edit DNA is at the heart of the synthetic biology value chain.
Yet researchers are constrained by existing synthesis technologies, both chemical and enzymatic, which can be error-prone, limited in their ability to produce sequences genome-wide, and crucially lack scalability for translation to high-throughput environments.
gSynth® has turned that on its head.
Any sequence, any length, any complexity
The gSynth® platform consists of four core pillars. Together they address the challenges of accuracy, length, scale, and speed, bringing a complete solution to the production of synthetic genes:
- Enzyme mix utilizing a uniquely optimized ligation-based ‘cut and paste’ method
- A highly pure class of reagent building blocks Addamers®
- Proprietary bioinformatics algorithm, Cimban™ that designs gene production from de novo
- Fermentation-based reagent production, creating wholly natural green synthesis
How it works
The gSynth advantage
- Generic reagent set compatible with common liquid handlers
- Pooled reactions allowing for small payload
- Uses a combinatorial and parallel assembly approach. Bypassing time-consuming and error-prone single base sequential methods or reliance on large libraries
- Based on ligation ‘cut and paste’ method that yields high efficiency and control over length
- Produces readily clonable dsDNA
- Proprietary bioinformatics design software that can be integrated to existing workflows
- Designed on geometric principles to access any sequence, via proprietary bioinformatics algorithm
- Supply-chain security
- Reduced timelines and therefore cost
Sustainability
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Unique selling point
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Unique selling point
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Unique selling point
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A secure and quick process from initiation to license.
Step 1
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Step 2
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Step 3
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